The fourth-round tie is being staged at Old Trafford, with tickets still available. Kick-off is at 19:00 GMT and the action is also being shown live on MUTV.
The Reds overcame Peterborough United 1-0 in the previous round, getting a taste for the Theatre of Dreams, with schoolboy forward Gabriel netting the only goal of the game.
This is the side's first competitive outing of 2026, following a winter break.
Darren Fletcher is in charge of the youngsters, after his two-match stint as interim head coach of the first team, and he will be looking for his players to enjoy the experience of competing on the big stage again.